I mistrust all systematizers and I avoid them. The will to a system is a lack of integrity. (Friedrich Nietzsche, Twilight of the Idols)
Nietzsche, the aphorist par excellence, put the problem most succinctly: constructing a framework is worthwhile only insofar as someone is willing to throw it away. It is the inevitable urge of any intellectual to extend their framework until it touches upon all aspects of life, becoming a world-view that explains all. Most intellectuals believe that the gap between the the world-view and the world can be crossed, and known to have been crossed, if we are diligent and wise; however, the will to a system forgets that a world-view can never be mapped one-to-one to the world.
If one holds on to their world-view, they are committed to its authority; they are a slave to the world-view. If one is willing to give up on their world-view, they are free.